Keep sealed and store in cool, dry conditions. Can be stored at room temperature without the need for refrigeration. In high, ambient temperatures (25°C+) air-conditioning or refrigeration would be cautionary to assist in maintaining shelf life. Total bacteria count viable until end of shelf life. Directions for use: 1 - 2 capsules once or twice daily with food. If taking two or more capsules daily, you may wish to split the dose between two meals. If you are taking antibiotics: Take 4 capsules daily, ideally at a different time of the day from the antibiotics. Continue taking for at least 2 weeks after completion of the antibiotic course. For travellers: 2 weeks before travel follow guidelines for general use. During travel take 4 capsules daily. Continue to take for at least 2 weeks following the end of travel. Children: Children under 12 - half adult dose.